Journal article
Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia
F Gu, H Zhang, PL Hyland, S Berndt, SM Gapstur, W Wheeler, CI Amos, S Bezieau, H Bickeböller, H Brenner, P Brennan, J Chang-Claude, DV Conti, JA Doherty, SB Gruber, TA Harrison, RB Hayes, M Hoffmeister, RS Houlston, RJ Hung Show all
International Journal of Cancer | Published : 2017
DOI: 10.1002/ijc.30883
Abstract
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
Grant sponsor: National Institute of Health; Grant numbers: U19 CA148127-01 (PI: Amos) and 1U19CA148127-02 (PI: Bickeboller); Grant sponsor: Canadian Cancer Society Research institute; Grant number: 020214 (PI: Hung); Grant sponsor: National Institute of Health; Grant number: U19 CA148065; Grant sponsor: National Institute of Health; Grant number: U19 CA148065; Grant sponsor: National Institute of Health; Grant numbers: U19 CA148107; R01 CA81488, P30 CA014089; Grant sponsor: GAME-ON U19 initiative for prostate cancer; Grant number: U19 CA148537; Grant sponsor: National Institute of Health; Grant number: U19 CA148107; R01 CA81488, P30 CA014089; Grant sponsor: GAME-ON U19 initiative for prostate cancer; Grant number: U19 CA148537; Grant sponsor: National Institutes of Health; Grant number: U19 CA148112-01 (PI: Sellers) and R01-CA149429 (Phelan); Grant sponsors: National Cancer Institute, National Institutes of Health, US Department of Health and Human Services; Grant numbers: U01 CA137088 and R01 CA059045; Grant sponsors: Regional Council of Pays de la Loire, the Groupement des Entreprises Francaises dans la Lutte contre le Cancer (GEFLUC), the Association Anne de Bretagne Genetique and the Liguc Regionale Centre le Cancer [(LRCC); ASTERISK: a Hospital Clinical Research Program (PHRC)]; Grant sponsor: German Research Council; Grant numbers: BR 1704/6-1, BR 1704/6-3, BR 1704/6-4 and CH 117/1-1); Grant sponsor: German Federal Ministry of Education and Research; Grant numbers: 01KH0404 and 01ER0814; Grant sponsor: National Institutes of Health; Grant number: R01 CA48998 (to M.L.S.); Grant sponsor: National Institutes of Health; Grant numbers: P01 CA 055075, UM1 CA167552, R01 137178, R01 CA 151993 and P50 CA 127003; Grant sponsor: National Institutes of Health; Grant numbers: R01 CA137178, P01 CA 087969, R01 CA151993 and P50 CA 127003); Grant sponsor: National Institutes of Health; Grant number: R01 CA042182; Grant sponsor: National Institutes of Health (through funding allocated to the Ontario Registry for Studies of Familial Colorectal Cancer; see CFR section); Grant number: U01 CA074783; Grant sponsors: Ontario Research Fund, the Canadian Institutes of Health Research, and the Ontario Institute for Cancer Research, through generous support from the Ontario Ministry of Research and Innovation (Additional funding toward genetic analyses of OFCCR); Grant sponsors: National Cancer Institute [NIH, Division of Cancer Prevention, DHHS (PLCO: Intramural Research Program of the Division of Cancer Epidemiology and Genetics)]; Grant sponsor: National Institutes of Health (NIH) and Genes, Environment, and Health Initiative [GEI (Lung Cancer and Smoking study)]; Grant numbers: Z01 CP 010200, NIH U01 HG004446 and NIH GEI U01 HG 004438; Grant sponsor: GENEVA Coordinating Center provided assistance with genotype cleaning and general study coordination, and the Johns Hopkins University Center for Inherited Disease Research conducted genotyping (For the lung study); Grant sponsor: National Institutes of Health; Grant number: R01 CA076366 (to PA Newcomb); Grant sponsor:.; Grant sponsor: National Institutes of Health; Grant number: K05 CA154337; Grant sponsor: National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services; Grant numbers: HHSN268201100046C, HHSN268201100001C, FIHSN268201100002C, HESN268201100003C, HHSN268201100004C and HHSN271201100004C; Grant sponsor: Swedish Cancer Foundation; Grant numbers: 09-0677, 11-484, 12-823; Grant sponsor: The Cancer Risk Prediction Center (CRisP; www. crispcenter.org), a Linneus Centre; Grant number: 70867902; Grant sponsor: Swedish Research Council; Grant numbers: K2010-70X-20430-04-3, 2014-2269; Grant sponsor: Canadian Institutes of Health Research (European Commission's Seventh Framework Programme grant agreement; CRUK GWAS); Grant number: 223175 (HEALTH-F2-2009-223175); Grant sponsor: Cancer Research UK; Grant numbers: C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692 and C16913/A6135; Grant sponsor: National Institute of Health (NIH; Cancer Post-Cancer GWAS initiative grant); Grant number: 1 U19 CA 148537-01 (the GAME-ON initiative); Grant sponsors: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK and The National Cancer Research Institute (NCRI) UK; Grant sponsor: NIHR (NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust); Grant sponsor: The National Health and Medical Research Council, Australia (The Prostate Cancer Program of Cancer Council Victoria); Grant numbers: 126402, 209057, 251533, 396414, 450104, 504700, 504702, 504715, 623204, 940394 and 614296,); Grant sponsors: VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall's; Grant sponsor: National Human Genome Research Institute for their support (EAO, DMK, and EMK acknowledge the Intramural Program)